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http://nopr.niscair.res.in/handle/123456789/35168
Title: | Synthesis of trans-resveratrol using modified Julia olefination route |
Authors: | Shenvi, Suvarna Shivanna, Shivaprakash Reddy, G Chandrasekara |
Keywords: | Julia olefination;Stilbenes;Benzothiazol-2-yl sulfone;p-anisaldehyde;trans-resveratrol;Veratrum album |
Issue Date: | Aug-2016 |
Publisher: | NISCAIR-CSIR, India |
Abstract: | Bioactive hydroxystilbinoid−trans-resveratrol [(E)-3,5,4ʹ-trihydroxy stilbene, 1] has been synthesized by modified Julia olefination method. The reaction between corresponding carbanion of benzothiazol-2-yl sulfone derivative and p-anisaldehyde dimethyl acetal with sodium hydride as a base, affords mainly cis-3,5,4ʹ-trimethoxystilbene 10b with minor quantity of trans-isomer. Both the isomers have been separated in pure form and confirmed by their NMR spectral data. Demethylation of cis-3,5,4ʹ-trimethoxystilbene either with AlCl3/pyridine or AlCl3/triethylamine results in the formation of trans-resveratrol. |
Page(s): | 1035-1038 |
URI: | http://nopr.niscair.res.in/handle/123456789/35168 |
ISSN: | 0975-0983(Online); 0376-4699(Print) |
Appears in Collections: | IJC-B Vol.55B(08) [August 2016] |
Files in This Item:
File | Description | Size | Format | |
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IJCB 55B(8) 1035-1038.pdf | 76.4 kB | Adobe PDF | View/Open |
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