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Title: Glycerol mediated green and one-pot synthesis of 6-amino-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitriles under catalyst free conditions
Authors: Vekariya, Rajesh H
Patel, Hitesh D
Keywords: 1,4-Dihydropyrano[2,3-c]-pyrazole-5-carbonitrile derivatives;One-pot;Glycerol;Catalyst free;Green synthesis
Issue Date: Aug-2016
Publisher: NISCAIR-CSIR, India
Abstract: A concise, facile and straightforward synthetic protocol has been described for the preparation of 6-amino-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitrile derivatives by a one-pot, three-component reaction of ethyl acetoacetate, hydrazine hydrate, aryl aldehydes and malononitrile in glycerol as a green and reusable reaction media under catalyst free condition. The corresponding 6-amino-1,4-dihydropyrano[2,3-c]-pyrazole-5-carbonitriles have been obtained with good to excellent yields (86-92%). This protocol is highly efficient due to its mild reaction conditions, operational simplicity, use of inexpensive, eco-friendly and green reaction media, catalyst-free conditions and absence of toxic organic solvents.
Page(s): 999-1006
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.55B(08) [August 2016]

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