Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/35162
Title: Synthesis of furoxan derivatives of diclofenac as potent anti-inflammatory agents with reduced GI toxicity
Authors: Amir, Mohd
Akhter, Md Wasim
Somakala, K
Keywords: Diclofenac;Nitric oxide donors;Furoxan;Anti-inflammatory;Ulcerogenicity;Lipid peroxidation;Hepatotoxic effect;Histopathological studies
Issue Date: Aug-2016
Publisher: NISCAIR-CSIR, India
Abstract: A new series of NO donating furoxan derivatives of diclofenac have been synthesized by linking diclofenac to selected furoxan moieties and have been investigated for their anti-inflammatory, analgesic, ulcerogenic, lipid peroxidation, hepatotoxicity, histopathological and NO releasing properties. All the hybrid derivatives are endowed with anti-inflammatory activity comparable to diclofenac but unlike this drug they show reduced GI toxicity. The compounds 4-[(2-(2-(2-(2,6-dichlorophenylamino)phenyl)acetamido)ethoxy)carbonyl]-3-methyl furoxan 12 having amide-ester linkage and 4-[(2-(2-(2,6-dichlorophenylamino)phenyl)acetoxy)methyl]-3-methyl-furoxan 13a having ester linkage show greater anti-inflammatory activity comparable to standard drug diclofenac. These compounds 12 and 13a also show higher gastrointestinal protection in comparison to standard drug diclofenac.
Page(s): 989-998
URI: http://nopr.niscair.res.in/handle/123456789/35162
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.55B(08) [August 2016]

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