Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/35145
Title: Synergistic protective effect of picrorhiza with honey in acetaminophen induced hepatic injury
Authors: Gupta, Prashant
Tripathi, Alok
Agrawal, Tripti
Narayan, Chandradeo
Singh, BM
Kumar, Mohan
Kumar, Arvind
Keywords: Ayurvedic;Liver damage;Hepatoprotective;Hepatoregenerative;Herbal;Kutki;Picroliv;Picrovin;SGPT;SGOT
Issue Date: Aug-2016
Publisher: NISCAIR-CSIR, India
Abstract: Rhizome of picrorhiza along with honey prevents hepatic damage and cure the acetaminophen (paracetamol) induced hepatotoxicity by modulating the activity of hepatic enzymes. Here, we studied the in vivo effects of Picrorhiza kurroa and honey on acetaminophen induced hepatotoxicity Balb/c mice model. Hepatic histopathological observations of acetaminophen fed (day-6) group showed more congestion, hemorrhage, necrosis, distorted hepatic architecture and nuclear inclusion. Such damages were recompensed to normal by picrorhiza or honey alone or both in combinations. We observed increased activity of SGPT and SGOT in injured liver tissues, and that too was compensated to normal with picrorhiza or honey alone or both in combinations. We observed 1.27 and 1.23-fold enhanced activity of SGPT in serum and liver lysate, respectively while SGOT showed 1.66 and 1.11 fold enhanced activity. These two enzymes are signature enzymes of liver damage. Thus, our results support that honey may be used with drug picrorhiza due to its synergistic role to enhance hepatoprotective and hepatoregenerative ability along with allopathic drugs to mitigate the hepatotoxic effects.
Page(s): 530-536
URI: http://nopr.niscair.res.in/handle/123456789/35145
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.54(08) [August 2016]

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