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Title: Age-related changes in the elemental constituents and molecular behaviour of bone
Authors: Rai, D V
Darbari, R
Aggarwal, L M
Keywords: Bone;Rat;Energy dispersive X-ray;Elemental analysis;Hydroxyapatite;IR spectra;Age-related changes
Issue Date: Apr-2005
Publisher: CSIR
IPC Code: G01N 33/50
Abstract: Age-related changes in bone composition within the age groups of 30, 60, 120 and 180 days in rats have been studied using thermogravimetery, elemental analysis and energy dispersive X-ray (ED X-ray). The structural changes in rats the bone samples were monitored by IR spectroscopy. The main constituents of hydroxyapatite, namely Ca, P and their oxides were analyzed. Organic changes, such as C and N contents in the matrix were found to have a predominant role in the initial development of the bone. An incremental increase in the mineral content of bone with advancing age was also observed. Elemental composition (C and N contents) was observed to be independent of age at the initial stages. The amount of Ca and its oxide content was found to increase, and the P and its oxides showed a decreasing trend, with the advancing age. IR spectra revealed that the mineral phase comprised both amorphous and crystalline hydroxyapatite, even at maturity; the amorphous content being higher at the earlier stages (14.09%, at 30 days), but was gradually replaced by crystalline component with advancing age (63.09% at 180 days). The present data may be useful in explaining the ageing phenomenon and helpful in understanding the bone growth and remodeling.
Page(s): 127-130
ISSN: 0301-1208
Appears in Collections:IJBB Vol.42(2) [April 2005]

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