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|Title:||Enantiospecific total synthesis of ent-10,11-thapsan-10-ol|
|Abstract:||First enantiospecific total synthesis of optical antipode of the sesquiterpene 10,11-epoxythapsan-10-ol has been described. (R)-Carvone has been employed as the chiral starting material and a combination of intramolecular alkylation and Criegee fragmentation are employed for intramolecular stereospecific transfer of the chirality. An intramolecular diazoketone cyclopropanation and regioselective cyclopropane ring cleavage reactions have been employed for the creation of the three requisite contiguous quaternary carbon atoms.|
|Appears in Collections:||IJC-B Vol.48B(03) [March 2009]|
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