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Title: Synthesis, characterization and antimicrobial evaluation of (E)- 4-(substitutedphenyl)-N'-(1-phenylethylidene)cyclohexane carbohydrazide derivatives
Authors: Venkatasatyanarayana, G
Rao, V Lakshmana
Laxminarayana, E
Chary, M Thirumala
Keywords: Antibacterial activity;Synthesis;Hydrazones;Gram positive bacteria;Atovaquone
Issue Date: Jun-2016
Publisher: NISCAIR-CSIR, India
Abstract: Encouraged by the various biological activities associated with hydrazone derivatives, the present paper describes the synthesis, characterization and antimicrobial evaluation of (E)-4-(substituted phenyl)-N'-(1-phenylethylidene) cyclohexanecarbohydrazide derivatives 4a-k from commercially available 4-(4-chlorophenyl)cyclohexanecarboxylic acid. The hydrazide-hydrazone derivatives 4a-k have been synthesized via the nucleophilic addition-elimination reaction of substituted acetophenones a-k with 4-(4-chlorophenyl)cyclohexanecarbohydrazide 3. The structures of the synthesized compounds are confirmed by 1H NMR, IR and mass spectral data. All the synthesized 4-(4-chlorophenyl)cyclohexane carbohydrazide derivatives 4a-k have been evaluated for their in vitro antibacterial activity against Staphylococcus aureus and Staphylococcus pyogenes (gram positive bacteria) and Escherichia coli and Pseudomonas aeruginosa (gram negative bacteria). The antibacterial screening results reveal that compounds 4f-j exhibit good antibacterial activity with zone of inhibition 21-25 mm while the compounds 4a-c show moderate antibacterial activity with zone of inhibition 16-20 mm whereas the compounds 4d, 4e and 4k show nil activity.
Page(s): 718-723
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.55B(06) [June 2016]

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