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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.48B [2009] >
IJC-B Vol.48B(02) [February 2009] >
| Title: | Synthesis and antibacterial activity of 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naphthyridin-2-yl]pyrazoles |
| Authors: | Mogilaiah, K
Vidya, K
Kavitha, S
Kumar, K Shiva |
| Keywords: | 2-Hydrazino-3-(3-chlorophenyl)-1,8-naphthyridine
Acetophenones
1,8-naphthyridin-2-ylhydrazones
Vilsmeier-Haack reagent
1,8-naphthyridinyl-pyrazoles |
| Issue Date: | Feb-2009 |
| Publisher: | CSIR |
| Abstract: | Condensation of 2-hydrazino-3-(3-chlorophenyl)-1,8-naph¬thyridine 2 with different acetophenones in methanol containing a catalytic amount of glacial acetic acid affords the corresponding aceto¬phenone 3-(3-chlorophenyl)-1,8-naphthyridin-2-ylhydra¬zones 3 in excellent yields. The hydrazones 3 when subjected to the Vilsmeier-Haack reaction with POCl₃-DMF gives 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naphthyridin-2-yl]pyrazoles 4 in good yields. The structural assignments to compounds 3 and 4 are based on their elemental analyses and spectral data. Compounds 4 have been tested for their antibacterial activity. |
| Page(s): | 282-285 |
| ISSN: | 0376-4699 |
| Source: | IJC-B Vol.48B(02) [February 2009]
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