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Title: Synthesis and antibacterial activity of 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naphthyridin-2-yl]pyrazoles
Authors: Mogilaiah, K
Vidya, K
Kavitha, S
Kumar, K Shiva
Keywords: 2-Hydrazino-3-(3-chlorophenyl)-1,8-naphthyridine;Acetophenones;1,8-naphthyridin-2-ylhydrazones;Vilsmeier-Haack reagent;1,8-naphthyridinyl-pyrazoles
Issue Date: Feb-2009
Publisher: CSIR
Abstract: Condensation of 2-hydrazino-3-(3-chlorophenyl)-1,8-naph¬thyridine 2 with different acetophenones in methanol containing a catalytic amount of glacial acetic acid affords the corresponding aceto¬phenone 3-(3-chlorophenyl)-1,8-naphthyridin-2-ylhydra¬zones 3 in excellent yields. The hydrazones 3 when subjected to the Vilsmeier-Haack reaction with POCl₃-DMF gives 3-aryl-4-formyl-1-[3-(3-chlorophenyl)-1,8-naphthyridin-2-yl]pyrazoles 4 in good yields. The structural assignments to compounds 3 and 4 are based on their elemental analyses and spectral data. Compounds 4 have been tested for their antibacterial activity.
Page(s): 282-285
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.48B(02) [February 2009]

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