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Title: Synthesis, anti-inflammatory and analgesic activity evaluation of some pyrimidine derivatives
Authors: Sondhi, Sham M
Dinodia, Monica
Rani, Reshma
Shukla, Rakesh
Raghubir, Ram
Keywords: Pyrimidines;Carrageenan;Anti-inflammatory;Analgesic
Issue Date: Feb-2009
Publisher: CSIR
Abstract: A number of pyrimidine derivatives 1-3, 5-19 have been synthesized by condensation of bis(2-(vinyloxy))ethylamine, cyclopropylamine, N-(2-amino-4-ethoxyphenyl)acetamide, 2-(aminomethyl thiophene), 2-thiophen ethylamine, 2-hydrazinopyridine, 1-aminonaphthalen-2-ol hydrochloride, furfuryl amine, 2-(4-imidazolyl)ethylamine, 2-picolylamine and 4-methoxyl-2-nitroaniline with various isothiocyanatoketones. These compounds have been screened for anti-inflammatory and analgesic activities. Compounds 10 and 14 have exhibited 40% and 39% anti-inflammatory and compound 11 has showed 75% analgesic activity at 100 mg/kg p.o. respectively.
Page(s): 273-281
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.48B(02) [February 2009]

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