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Title: Synthesis and anti-bacterial evaluation of 4-aryloxymethyl carbostyrils derived from substructures and degradation products of Vancomycin
Authors: Revankar, Hrishikesh M
Arali, Shweta
Yakkerimath, Shilpa
Revankar, Pooja P
Naik, Vijaykumar
Anand, Ashish
Kulkarni, Manohar V
Keywords: Ethyl gallate;N-benzoyl tyrosine ethyl ester;Antibacterial activity;Gram-positive;4-bromomethyl carbostyril
Issue Date: May-2016
Publisher: NISCAIR-CSIR, India
Abstract: Vancomycin has been used as an antibiotic selectively against Gram-positive bacteria; however in the past decade they have grown resistant against it. The present work describes synthesis of a series of 4-aryloxymethyl carbostyrils derived from the reaction of 4-bromomethyl carbostryils with degradation products of Vancomycin (ethyl gallate and ethyl ester of N-benzoyl tyrosine ethyl ester). Further, gallate ethers 4a-d and tyrosine ethers 5a-d have been found to be selectively active against Gram-positive bacteria.
Page(s): 637-642
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.55B(05) [May 2016]

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