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Title: Facile, high regio- and chemoselective conversion of epoxides to β-chlorohydrins using chlorodiphenylphosphine under solvent-free conditions
Authors: Aghapour, Ghasem
Afzali, Asieh
Salek, Fahimeh
Keywords: Epoxides;β-chlorohydrins;Chemoselectivity;Chlorodiphenylphosphine;Solvent-free
Issue Date: Feb-2009
Publisher: CSIR
Abstract: A new method is described for the mild and high regioselective conversion of epoxides to β-chlorohydrins in high yields even in the presence of alcohols, carboxylic acids, oximes, amides, thiols and tetrahydropyranyl ethers using chlorodiphenylphosphine (ClPPh₂) under solvent-free and neutral conditions at room temperature and in short reaction times. In addition, some other functional groups such as carbon-carbon double bonds, ester groups and also phenyl ring that are present in the epoxide molecules remain intact in this method.
Page(s): 231-236
ISSN: 0376-4699
Appears in Collections:IJC-B Vol.48B(02) [February 2009]

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