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Title: Synthesis and antibacterial activity of di-heteryl substitued [1,2,4]triazolo [3,4-b][1,3,4]thiadiazoles
Authors: Reddy, Ch Sanjeeva
Devi, M Vani
Sunitha, M
Kalyani, B
Nagaraj, A
Keywords: Triazoles;Triazolo[3,4-b][1,3,4]thiadiazole;Antibacterial activity
Issue Date: May-2016
Publisher: NISCAIR-CSIR, India
Abstract: A new series of 3-(5-methyl-1-phenyl-1H-4-pyrazolyl)-6-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl)[1,2,4]triazolo [3,4-b][1,3,4]thiadiazoles 12a-j have been prepared and assayed for their antibacterial activity against human pathogenic Gram-positive bacteria viz., Staphylococcus aureus, Bacillus subtilis and Gram-negative Escherichia coli. Among the screened compounds 12b, 12c and 12f, in which phenyl ring of triazole moiety bear 4-chloro, 4-nitro and 4-fluoro substituents respectively, showed high activity against all the micro-organisms employed. The activities of these compounds are almost equal to the standards.
Page(s): 590-597
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.55B(05) [May 2016]

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