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|Title:||A new fragmentation rearrangement of the N-terminal protected|
|Keywords:||Terminal-protected amino acids;ESI-MS/MS;Electronic migration;Rearrangement|
|Abstract:||A novel fragmentation rearrangement reaction with a carboxyl oxygen negative charge migration was observed in the N-terminal protected amino acids including Fmoc-protected phosphoserine, phosphothroenine, and phosphotyrosine and their analogues using the electrospray ionization tandem mass spectrometry (ESI-MS/MS). The possible mechanism of a five-membered ring transition state was proposed and supported by the further experiments. It was found that the tendency of the rearrangement was determined by the blocking status of its C-terminal and the reaction was proved to be independent of the N-terminal and side-chain protecting groups of the amino acids.|
|Appears in Collections:||IJBB Vol.43(6) [December 2006]|
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