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IJBB Vol.43(6) [December 2006] >


Title: A new fragmentation rearrangement of the N-terminal protected
Authors: Zhu, Zhen-Tai
Li, Yan-Mei
Guo, Yan-Ting
Sun, Ming
Zhao, Yu-Fen
Keywords: Terminal-protected amino acids
ESI-MS/MS
Electronic migration
Rearrangement
Issue Date: 2006
Publisher: CSIR
Abstract: A novel fragmentation rearrangement reaction with a carboxyl oxygen negative charge migration was observed in the N-terminal protected amino acids including Fmoc-protected phosphoserine, phosphothroenine, and phosphotyrosine and their analogues using the electrospray ionization tandem mass spectrometry (ESI-MS/MS). The possible mechanism of a five-membered ring transition state was proposed and supported by the further experiments. It was found that the tendency of the rearrangement was determined by the blocking status of its C-terminal and the reaction was proved to be independent of the N-terminal and side-chain protecting groups of the amino acids.
Page(s): 372-376
ISSN: 0301-1208
Source:IJBB Vol.43(6) [December 2006]

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