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|Title:||Antibacterial Property of Halobacterial Carotenoids against Human Bacterial Pathogens|
|Keywords:||Antibacterial activity;Antibiotic resistant pathogens;Halomonas sp.;Ophthalmic pathogens|
|Abstract:||The present study was aimed to find out the antibacterial potential of caroteniods from halobacteria isolated from saltpan sediments against antibiotic resistant pathogens (Klebsiella sp., Staphylococcus aureus, Pseudomonas aeroginosa, Streptococcus pneumoniae and Streptococcus epidermis) and ophthalmic pathogens (E.coli, Staphylococcus aureus, Streptococcus pyogens, Proteus sp. and Acinitobacter sp). Different concentrations of the carotenoids were analyzed by MIC and MBC techniques. The isolates were identified by 16S rRNA gene sequencing and the relationship between the isolates was identified by phylogenetic tree analysis. Among the isolates, KT-02 showed maximum (14±0.65 mm dia.) sensitivity against Klebsiella sp. followed by 13±0.65 mm dia. against E.coli. The MIC and MBC values varied between 128-512 µg.ml-1. The potential isolate KT-02 showed maximum similarity (>95%) with Halomonas sp. (EU 435355) and the 16s rRNA secondary structure showed 15 loops and 23 turns and the free energy value was identified as -121.2 kkal/mol.|
|ISSN:||0975-1084 (Online); 0022-4456 (Print)|
|Appears in Collections:||JSIR Vol.75(04) [April 2016]|
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