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Title: Single nucleotide polymorphism of SLC11A1, CARD15, IFNG and TLR2 genes and their association with Mycobacterium avium subspecies paratuberculosis infection in native Indian cattle population
Authors: Sadana, Tarun
Singh, Ran Vir
Singh, Shoor Vir
Saxena, Vishesh Kumar
Sharma, Deepak
Singh, Pravin Kumar
Kumar, Naveen
Gupta, Saurabh
Chaubey, Kundan Kumar
Jayaraman, Sujata
Tiwari, Ruchi
Dhama, Kuldeep
Bhatia, Ashok Kumar
Sohal, Jagdip Singh
Keywords: Host susceptibility;Genetic resistance;Indian cattle;Johne’s disease;Paratuberculosis
Issue Date: Oct-2015
Publisher: NISCAIR-CSIR, India
Abstract: Johne’s disease (JD) or paratuberculosis infection, caused by Mycobacterium avium subspecies paratuberculosis (MAP), is one of the major production diseases of domestic animals. There is lack of preventive and chemotherapeutic measures to control this infection. Hence, in recent years emphasis has been given to identify host genetic factors associated with resistance to infection. In the present study, we analyzed SNPs in four candidate genes (SLC11A1, TLRs, NOD2/CARD and IFNγ) in case and control population of native breeds of cattle. Of the four genes only SNP in TLR2 gene showed significant association with resistance to paratuberculosis infection. The results of the present study are promising and it is predicted that such studies will serve as guidelines in future breeding programmes.
Page(s): 469-475
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.14(4) [October 2015]

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