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dc.contributor.authorGupta, Sarita-
dc.contributor.authorVerma, Purnima-
dc.contributor.authorSingh, Virendra-
dc.identifier.issn0975-0983(Online); 0376-4699(Print)-
dc.description.abstractA series of thiol derivatives containing imidazole moiety have been synthesized by cyclisation of ethyl acetoacetate with substituted aromatic amines in presence of potassium thiocynate to form tetra substituted compounds which are oxidized in presence of selenium dioxide to afford diketo compound 2-(4-ethoxy-1-(4-hydroxyphenyl)-2-mercapto-1H-imidazol-5-yl)-2-oxoacetaldehyde 2. The compound 2 on condensation with different aromatic aldehydes forms thiol derivatives 3a-j. The structural elucidation of all the synthesized compounds have been confirmed by their spectral/elemental data analysis. All the synthesized thiol derivatives have been investigated for their antibacterial and antifungal activity and show moderate to very good activity.en_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJC-B Vol.55B(03) [March 2016]en_US
dc.subjectEthyl acetoacetateen_US
dc.subjectSubstituted aromatic aminesen_US
dc.subjectAromatic aldehydesen_US
dc.subjectPotassium thiocynateen_US
dc.subjectSelenium dioxideen_US
dc.titleSynthesis and biological studies of thiol derivatives containing imidazole moietyen_US
Appears in Collections:IJC-B Vol.55B(03) [March 2016]

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