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Title: Study on the antiproliferative activity of four Schiff bases derived from natural biomass dehydroabietylamine
Authors: Luo, Hui
Sui, Yan
Lin, Wen-Hua
Wu, Hong-Qin
Keywords: Dehydroabietylamine;Schiff base;Antiproliferative activitiy;Structure-activity relationship
Issue Date: Feb-2016
Publisher: NISCAIR-CSIR, India
Abstract: Four Schiff bases (1-4) have been obtained by the reaction of dehydroabietylamine and 5-fluoro-2-hydroxybenzaldehyde, 5-chloro-2-hydroxybenzaldehyde, 5-bromo-2-hydroxybenzaldehyde and 2-hydroxy-5-nitrobenzaldehyde, respectively. They have been evaluated for their antiproliferative activities over A549, NCI-H460 and SW620. Among them, 4 exhibits the highest antiproliferative activity. IC50 values are only 8.27, 2.98 and 7.14 μM for NCI-H460, SW620 and A549 cell lines, respectively.
Page(s): 248-251
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.55B(02) [February 2016]

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