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Title: Synthesis of some piperazinobenzoxazole derivatives and their antimicrobial properties
Authors: Arisoy, Mustafa
Temiz-Arpaci, Ozlem
Kaynak-Onurdag, Fatma
Ozgen, Selda
Keywords: Benzoxazole;Propionamide;Antifungal activity;Antibacterial activity;Piperazine
Issue Date: Feb-2016
Publisher: NISCAIR-CSIR, India
Abstract: A series of 2-(p-substitutedphenyl/benzyl)-5-[3-[4-[(p-chlorophenyl)/phenyl]piperazin-1-yl]propionamido]-benzoxazoles (3-22) have been synthesized towards discovering new antimicrobial compounds in order to fight against pathogens, which have become resistant to antibiotics and are the cause of increased mortality and morbidity throughout the world. Structures of new derivatives have been elucidated by spectral techniques. New and previously synthesized benzoxazoles have been evaluated for their antibacterial and antifungal activity against standard strains, and their drug-resistant isolates in comparison with reference drugs. This study is aimed to investigate the efficacy of the antimicrobial effect of different amido bridges on the same homologue structures of benzoxazole compounds. Compounds 3-22 exhibit broad antibacterial activity with MIC (Minimum Inhibitory Concentration) values of 128-256 µg/mL against Staphylococcus aureus and its isolate except for derivative 7 that has a MIC value of 32 µg/mL against S. aureus isolate and compounds 3 and 22 which have MIC value of 512 µg/mL against S. aureus. Also, the tested compounds 3-22 possess low antifungal activity with MIC values of 128 µg/mL against Candida albicans in comparison with antifungal reference drugs, fluconazole and amphotericin B.
Page(s): 240-247
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.55B(02) [February 2016]

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