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Title: Synthesis of 1,2,3-triazole glycosides as anticancer agents
Authors: Srinivas, A
Sunitha, M
Keywords: O-Methyl allose;Triazole glycosides;Click reaction;ZrCl4;Anticancer activity
Issue Date: Feb-2016
Publisher: NISCAIR-CSIR, India
Abstract: A series of novel 1,2,3-Triazole glycosides have been prepared by the addition reaction of O-methyl allose aldehyde with Grignard reagent. Subsequent treatment with TMSN3 gives the corresponding azide, which on reaction with alkynes gives 1,2,3-triazole glycosides. Characterization of all the compounds has been carried out by IR, 1H NMR, mass spectroscopy and elemental analysis. Anticancer activity of the compounds has also been evaluated.
Page(s): 231-239
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.55B(02) [February 2016]

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