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Title: Effect of Capparis spinosa Linn. extract on lipopolysaccharide-induced cognitive impairment in rats.
Authors: Goel, Ashish
Garg, Arun
Kumar, Ashok
Keywords: Caper Bush;Cholinesterase assay;Learning and Memory;Neurodegeneration;Stress
Issue Date: Feb-2016
Publisher: NISCAIR-CSIR, India
Abstract: Cognitive disorders in mankind are not uncommon. Apart from neurodegenerative diseases such as Alzheimer’s (AD), various stresses also affect cognitive functions. Plants are known to be potential source of compounds that ameliorate several diseases including cognitive impairment. Here, we evaluated effect of aqueous extract of caper (Capparis spinosa) buds on lipopolysaccharide-induced cognitive impairment in rats using two different oral doses i.e. 10 (pre-treatment) and 30 mg/rat(post-treatment) through assessment of behavioural (Morris Water maze test and Y maze test), biochemical (Cholinesterase assay) and histopathological (H&E staining) parameters. Lipopolysaccharide (from E. coli) administration resulted in an increased neurodegeneration and time taken to reach the platform (in Morris water maze). The increased neurodegeneration in CA1 region of hippocampus was significantly reduced in animals which received caper bud extract; they showedmarked reduction in time taken to reach the platform at both the dose levels. The experiment demonstrated that caper bud extract exhibits potential protective effect against learning and memory damage induced by chronic administration of lipopolysaccharide (175 µg/kg) for 7 days. The results suggest that the caper bud extract could be explored for its use in the treatment of cognitive disorders.
Page(s): 126-132
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections: IJEB Vol.54(02) [February 2016]

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