Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/33038
Title: Environmentally benign synthesis, antibacterial and anti-inflammatory activities of 3-aryl-1-{3-[2-(trifluoromethyl) phenyl][1,8]naphthyridin-2-yl}-1H-4-pyrazolecarbaldehydes
Authors: Mogilaiah, K
Rao, A Nageswara
Jyothi, S
Keywords: Pyrazole;1,8-naphthyridine;Vilsmeier-Haack reagent;Solid support;Microwave irradiation;Antibacterial activity;Anti-inflammatory activity
Issue Date: Nov-2015
Publisher: NISCAIR-CSIR, India
Abstract: A simple and efficient protocol for the transformation of 1-aryl-1-ethanone 1-{3-[2-(trifluoromethyl)phenyl][1,8]naphthyridin-2-yl}hydrazones 3 to 3-aryl-1-{3-[2-(trifluoromethyl) phenyl][1,8]-naphthyridin-2-yl}-1H-4-pyrazolecarbaldehydes 4 is reported under microwave irradiation utilizing POCl3-DMF over silica gel with high yields. The structures of the compounds 3 and 4 have been confirmed on the basis of their elemental analyses and spectral (IR, 1H NMR and MS) data. The compounds 4 have been evaluated for their antibacterial and anti-inflammatory activities.
Page(s): 1355-1359
URI: http://hdl.handle.net/123456789/33038
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.54B(11) [November 2015]

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