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Title: Carbohydrate hydrolyzing enzymes inhibitory and free radical scavenging activities of substituted 2H-chromene-3-carboxylates, 2H-chromenyl Knoevenagel derivatives and 6H-chromenoquinolinones
Authors: Vishnu, S
Srikanth, P
Tiwari, Ashok K
Kumar, D Anand
Raju, B China
Keywords: 2H-Chromene-3-carboxylates;2H-chromenyl Knoevenagel derivatives;6H-chromenoquino-linones;Salicylaldehydes;4-chloro-3-formylcoumarin;Anti-oxidant;Anti-diabetic
Issue Date: Nov-2015
Publisher: NISCAIR-CSIR, India
Abstract: Three series of compounds namely ethyl 2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylates 3a-q, 2H-chromenyl Knoevenagel derivatives 7a-j and 6H-chromenoquinolinones 9a-l have been prepared. The synthesized compounds 3a-q, 7a-j and 9a-g have been screened for anti-oxidant and anti-diabetic activity. Compound 3i shows the most potent ABTS inhibitory activity when compared to trolox. Compounds 3b, 3d, 3j and 3l show α-amylase inhibitory activity.
Page(s): 1332-1341
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.54B(11) [November 2015]

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