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Title: A brief review of Cherylline synthesis
Authors: Manolov, Stanimir P
Atanasova, Stoyanka N
Ghate, Manjunath
Ivanov, Iliyan I
Keywords: Amaryllidaceae alkaloids;Cherylline;Crinum;4-aryl-1,2,3,4-tetrahydroisoquinolines;Synthesis
Issue Date: Nov-2015
Publisher: NISCAIR-CSIR, India
Abstract: 1,2,3,4-Tetrahydroisoquinolines are an important class of synthetic and natural compounds, which display a broad range of medicinal activities. The 1,2,3,4-tetrahydroisoquinoline system has attracted attention not only because of its biological activities, but also due to its presence as a basic framework in many naturally occurring products and drugs. Their skeletons are unique among the Amaryllidaceae alkaloids and they have long been alluring targets for synthetic chemists as witnessed by a number of articles dealing with biogenesis, isolation, characterization and synthesis. The alkaloid cherylline is an optically active naturally occurring, 4-phenyl-1,2,3,4-tetrahydroisoquinoline alkaloid, isolated from Crinum powelli, Amaryllidaceae plant. There are many ways for cherylline synthesis. In this short review is described the different methods for synthesis of the alkaloid cherylline.
Page(s): 1301-1320
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.54B(11) [November 2015]

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