Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/33024
Title: Anti-leishmanial activity of Agave americana L.– A traditional Indian medicinal plant
Authors: Thakur, Chandreshwar Prasad
Narayan, Shyam
Bahadur, Shiv
Thakur, Meenakshi
Pandey, Sashi Nath
Kumar, Prabin
Misra, Pragya
Mukherjee, Pulok K
Mitra, Dipendra K
Keywords: Visceral leishmaniasis;Agave Americana L.;Promastigotes;MTT assay
Issue Date: Oct-2015
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, A01D 20/18, A01D 29/00, A01D 31/00, A01D 33/00, A01D 7/06
Abstract: Due to lack of safe treatment and developing resistance to the available drugs for visceral leishmaniasis or Kala-azar - a fatal parasitic disease caused by Leishmania donovani - the search for drugs from natural resources is imperative. In the present study, the comparative in vitro anti-leishmanial activity of various fractions of Agave americana extracts has been evaluated. Extracts were prepared through successive solvent extraction through Soxhlet apparatus using benzene, chloroform, ethyl acetate and methanol respectively. Among those extracts ethyl acetate fraction was capable of selectively inhibiting both stages of Leishmania donovani by generation of reactive oxygen and nitrogen species. Ethyl acetate fraction Agave americana showed significant antileishmanial activity (IC­50~25 µg/ml complete inhibition (IC90) at 50 µg/ml. This observation emphasizes the need to extend studies related to traditional medicines from botanicals for better and safe alternatives to the available anti-leishmanials.
Page(s): 658-663
URI: http://hdl.handle.net/123456789/33024
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.14(4) [October 2015]

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