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Title: Evaluation of anti-amnestic activity of few medicinal plants against scopolamine induced amnesia
Authors: Barua, Chandana Choudhury
Haloi, Prakash
Patowary, Pompy
Bora, Mondira
Barua, Acheenta Gohain
Bordoloi, Manab Jyoti
Barua, Iswar Chandra
Keywords: Dementia;Acorus calamus L.;Gnetum gnemon L.;Scopolamine;Acetylcholinesterase
Issue Date: Oct-2015
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, A01D 22/01, A01D 22/18, A01D 22/19, A01D 22/21, A01D 20/00, C12N 9/00, C12N 11/00, A61K 38/43
Abstract: Dementia is a syndrome of progressive nature, characterized by impairment of memory and loss of intellectual ability. Subsequently, allopathic system of medicine is yet to provide a fundamental cure; it is meaningful to look for novel directions, which would curtail the memory loss seen in elderly patients. We have screened few plants for enhancement of memory and learning in our laboratory as pilot study and found two plants, viz. Acorus calamus L. and Gnetum gnemon L. to be more promising than others. Hence, the rationale for this study was to evaluate the prospective beneficial effect of Acorus calamus and Gnetum gnemon on learning and memory in rats using Radial-arm maze and Barnes maze and Morris water maze in mice using a repeated acquisition procedure. A suspension preparation of A. calamus (200mg/kg) and G. gnemon (200mg/kg) was administered orally after completion of the specific training period. Memory loss was induced by Scopolamine (0.4mg/kg i.p.), a muscarinic cholinergic antagonist and a classic amnestic drug. Tacrine (3mg/kg i.p) was used as the standard drug. The data obtained from behavioral and biochemical studies (Acetylcholinesterase, MDA and nitrite estimation) have shown that G.gnemon, and A. calamus possessed significant memory enhancing potency. However, further studies are necessitated to identify the exact mechanism of action.
Page(s): 581-589
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.14(4) [October 2015]

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