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Title: Plant-based treatment of snakebites
Authors: Jäger, Anna K
Keywords: Africa;Necrosis enzymes;Snakebites;Skin permeability;Tissue necrosis;Wound healing
Issue Date: Oct-2015
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, A01D 15/14, A01D 15/00, A61Q17/00, A61B 17/00, A01D 20/47, A01D 20/48, A01D 6/00, A61B 17/03, A62F 13/00
Abstract: Snakebite is listed as a neglected tropical disease by the WHO. Up to 2.5 million people are bitten each year, resulting in up to 125.000 deaths, and 400.000 permanent disabilities due to tissue necrosis. We investigated 94 plant species from Africa, which are used in traditional medicine to treat snakebites, for inhibitory activity against the necrosis enzymes hyaluronidases, phospholipase A2 and proteases. Six species, which were active against one or more of the necrosis enzymes after tannins were removed, were investigated for their ability to penetrate skin and for their wound healing activity in the scratch assay. The extracts could not pass the skin membrane and showed cytotoxicity in the cell scratch assay. Therefore, none of these extracts can be recommended for treatment of snakebites – which is in line with official guidelines on not using plant extracts on snakebites.
Page(s): 571-573
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.14(4) [October 2015]

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