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Title: Effect of conventional antihypertensive drugs on hypolipidemic action of garlic in rats
Authors: Asdaq, Syed Mohammed Basheeruddin
Inamdar, Mohammed Naseeruddin
Asad, Mohammed
Keywords: Captopril;Garlic homogenate;Hydrochlorothiazide;Lipid profile;Propranolol.
Issue Date: Mar-2009
Publisher: CSIR
Abstract: The present study was undertaken to determine the possible alteration in hypolipidemic actions of garlic homogenate (GH) in presence of conventional antihypertensive drugs, propranolol (PRO), hydrochlorothiazide (HYD) and captopril (CAP). Albino rats fed with normal fat diet (NFD) or high fat diet (HFD) were treated with GH at three different doses (125, 250 and 500 mg/kg) orally for 30 days or in combination with PRO (10 mg/kg, po), HYD (10 mg/kg, po) and CAP (30 mg/kg, po) during last 7 days of GH treatment. After the treatment, total cholesterol (TC), LDL-cholesterol, triglyceride (TG) and HDL-cholesterol were measured in serum and antiatherogenic index was calculated. The result showed that moderate and high doses of GH possessed potential antiatherosclerotic property that was significantly attenuated by PRO and HYD. However, GH antihyperlipidemic activity was augmented by CAP. It was concluded that administration of PRO and HYD decrease the hypolipidemic effect of GH and administration of GH along with CAP augmented the hypolipidemic effect of GH in rats.
Page(s): 176-181
ISSN: 0019-5189
Appears in Collections:IJEB Vol.47(03) [March 2009]

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