Please use this identifier to cite or link to this item:
http://nopr.niscair.res.in/handle/123456789/3295
Title: | Anti-nociceptive effect of duloxetine in mouse model of diabetic neuropathic pain |
Authors: | Kuhad, Anurag Bishnoi, Mahendra Chopra, Kanwaljit |
Keywords: | Adenosine;Diabetes;Duloxetine;Neuropathy |
Issue Date: | Mar-2009 |
Publisher: | CSIR |
Abstract: | The involvement of adenosinergic pathway in the anti-nociceptive effect of duloxetine, a balanced 5-HT/NE reuptake inhibitor, was evaluated in streptozotocin induced diabetic male albino mice of Laca strain. After four weeks of single injection of streptozotocin (200 mg/kg, ip), mice were tested in the tail immersion and hot-plate assays. Cerebral adenosine levels were measured by high-performance liquid chromatography (HPLC/PDA detector). Diabetic mice exhibited significant hyperalgesia along with increased plasma glucose, decreased body weights and reduced cerebral adenosine levels. Administration of duloxetine (5, 10 and 20 mg/kg, ip) to diabetic mice produced dose-dependent anti-nociceptive effect in both tail-immersion and hot-plate assays. Adenosine levels were also significantly and dose-dependently increased by different doses of duloxetine. The results demonstrated the involvement of adenosinergic pathway in duloxetine mediated anti-hyperalgesia in diabetic neuropathic pain. |
Page(s): | 193-197 |
URI: | http://hdl.handle.net/123456789/3295 |
ISSN: | 0019-5189 |
Appears in Collections: | IJEB Vol.47(03) [March 2009] |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
IJEB 47(3) 193-197.pdf | 89 kB | Adobe PDF | View/Open |
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.