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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.47 [2009] >
IJEB Vol.47(03) [March 2009] >
| Title: | Anti-nociceptive effect of duloxetine in mouse model of diabetic neuropathic pain |
| Authors: | Kuhad, Anurag
Bishnoi, Mahendra
Chopra, Kanwaljit |
| Keywords: | Adenosine
Diabetes
Duloxetine
Neuropathy |
| Issue Date: | Mar-2009 |
| Publisher: | CSIR |
| Abstract: | The involvement of adenosinergic pathway in the anti-nociceptive effect of duloxetine, a balanced 5-HT/NE reuptake inhibitor, was evaluated in streptozotocin induced diabetic male albino mice of Laca strain. After four weeks of single injection of streptozotocin (200 mg/kg, ip), mice were tested in the tail immersion and hot-plate assays. Cerebral adenosine levels were measured by high-performance liquid chromatography (HPLC/PDA detector). Diabetic mice exhibited significant hyperalgesia along with increased plasma glucose, decreased body weights and reduced cerebral adenosine levels. Administration of duloxetine (5, 10 and 20 mg/kg, ip) to diabetic mice produced dose-dependent anti-nociceptive effect in both tail-immersion and hot-plate assays. Adenosine levels were also significantly and dose-dependently increased by different doses of duloxetine. The results demonstrated the involvement of adenosinergic pathway in duloxetine mediated anti-hyperalgesia in diabetic neuropathic pain. |
| Page(s): | 193-197 |
| ISSN: | 0019-5189 |
| Source: | IJEB Vol.47(03) [March 2009]
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