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Title: Anti-nociceptive effect of duloxetine in mouse model of diabetic neuropathic pain
Authors: Kuhad, Anurag
Bishnoi, Mahendra
Chopra, Kanwaljit
Keywords: Adenosine
Issue Date: Mar-2009
Publisher: CSIR
Abstract: The involvement of adenosinergic pathway in the anti-nociceptive effect of duloxetine, a balanced 5-HT/NE reuptake inhibitor, was evaluated in streptozotocin induced diabetic male albino mice of Laca strain. After four weeks of single injection of streptozotocin (200 mg/kg, ip), mice were tested in the tail immersion and hot-plate assays. Cerebral adenosine levels were measured by high-performance liquid chromatography (HPLC/PDA detector). Diabetic mice exhibited significant hyperalgesia along with increased plasma glucose, decreased body weights and reduced cerebral adenosine levels. Administration of duloxetine (5, 10 and 20 mg/kg, ip) to diabetic mice produced dose-dependent anti-nociceptive effect in both tail-immersion and hot-plate assays. Adenosine levels were also significantly and dose-dependently increased by different doses of duloxetine. The results demonstrated the involvement of adenosinergic pathway in duloxetine mediated anti-hyperalgesia in diabetic neuropathic pain.
Description: 193-197
ISSN: 0019-5189
Appears in Collections:IJEB Vol.47(03) [March 2009]

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