Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/32853
Title: Interaction of thiolated amino acids and peptide onto the gold nanoparticle surface: Radical scavenging activity
Authors: Satnami, Manmohan L
Chandraker, Kumudini
Vaishanav, Sandeep K
Nagwanshi, Rekha
Keywords: Interparticle interactions;Plasmon-plasmon interactions;Zwitterion-type electrostatic interactions;Self-assembly;Nanoparticles;Gold nanoparticles;Amino acids;Thiolated amino acids;Peptides;Radical scavenging;Scavenging
Issue Date: 21-Oct-2015
Publisher: NISCAIR-CSIR, India
Abstract: The interaction of gold nanoparticles (AuNPs) with thiolated amino acid, L-cysteine, and peptide, glutathione, is reported. Additionally, thioglycolic acid has also been employed to study the effect of other functional groups such as amine on interparticle interaction mechanism. The functionalized AuNPs have been characterized through UV-visible spectroscopy, FTIR analysis and transmission electron microscopy. The plasmon-plasmon interactions amongst the functionalized AuNPs are found to be dependent on ligand concentration, pH and salt environment. The assembly of AuNPs mediated by L-Cys and GSH has been monitored by the evolution of the surface plasmon resonance absorption. The optical spectra of AuNPs is shifted to the red region, indicating dipole-dipole interactions in the AuNPs assembly. The self-assembly is more pronounced in the case of amino acid and tripeptide, due to the zwitterion-type electrostatic interactions between amino acid groups of L-Cys/GSH bound to different NPs. Furthermore, the scavenging behavior of the studied thiolated ligands and the corresponding AuNPs has been studied by using 1,1-diphenyl 2-picryl hydrazil radical. AuNPs significantly reduces the radical scavenging ability of thiolated antioxidants.
Page(s): 1206-1214
URI: http://hdl.handle.net/123456789/32853
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.54A(10) [October 2015]

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