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Title: Metal-free reductive amination of aldehydes for the synthesis of secondary and tertiary amines
Authors: Ambica
Khajuria, Rajni
Saini, Yeshwinder
Kapoor, Kamal K
Keywords: Reductive amination;Transfer hydrogenation;Metal-free reduction;Benzimidazoline;Benzimidazole;N-alkylation
Issue Date: Oct-2015
Publisher: NISCAIR-CSIR, India
Abstract: Reductive amination of aldehydes to produce secondary amines at room-temperature by in situ generated benzimidazoline is discussed. The bonus of the reaction is the formation of pharmaceutically important benzimidazole as a by-product in good yield, which can be recovered from the reaction mixture by simple filtration. The product, secondary amine, is transformed to tertiary amine in the same pot.
Page(s): 1252-1259
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.54B(10) [October 2015]

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