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Title: Stereoselective reduction of δ-hydroxy β-ketoesters to syndiol in achiral micellar system
Authors: Roy, Bhairab Nath
Singh, Girij Pal
Lathi, Piyush Suresh
Agrawal, Manoj K
Mitra, Rangan
Keywords: Statin;Achiral;Micellar media;β-ketoester;Syndiol
Issue Date: Oct-2015
Publisher: NISCAIR-CSIR, India
Abstract: A novel, efficient and stereo-selective process for synthesis of statin side chain, a key intermediate for statin type cholesterol lowering drugs such as Lipitor (atorvastatin) and Crestor (rosuvastatin) in achiral micellar media is reported. The key feature of this process is sodium borohydride reduction of δ-hydroxy β-ketoester in achiral micellar system in 92% de, thereby avoiding metal chelation methods which employ triakylborane, titanium (IV) isopropoxide or cerium (III) chloride prior to reduction.
Page(s): 1247-1251
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.54B(10) [October 2015]

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