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IJBB Vol.43(3) [June 2006] >

Title: Vibrational dynamics of morphine in relation to Leu⁵- and Met⁵-enkephalins
Authors: Misra, Neeraj
Prasad, Onkar
Sinha, Leena
Keywords: Morphine
Opioid peptides
Vibrational dynamics
Charge distribution
Receptor interaction
Issue Date: Jun-2006
Publisher: CSIR
Abstract: A complete normal coordinate analysis of morphine using Wilson’s GF matrix method and Urey Bradley force field has been carried out to understand the dynamical behaviour of morphine in relation to Leu⁵- and Met⁵-enkephalins. In addition, charge distribution on different atoms of morphine, along with that of Leu⁵- and Met⁵-enkephalins using CNDO/2 method is also reported. The similarity in charge distribution on some of the sites of these molecules is indicative of the possible interactions at the same receptor site. It is surmised that the recognition and interaction of active sites with the receptor must be dynamical in nature and for this the modes involving the active sites should play an important role. It is found that the binding to receptors is not static, but a dynamic process.
Page(s): 173-181
ISSN: 0301-1208
Source:IJBB Vol.43(3) [June 2006]

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