Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/3253
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPatel, Anamika-
dc.contributor.authorMishra, Sandhya-
dc.contributor.authorGhosh, P K-
dc.date.accessioned2009-02-24T05:00:17Z-
dc.date.available2009-02-24T05:00:17Z-
dc.date.issued2006-02-
dc.identifier.issn0301-1208-
dc.identifier.urihttp://hdl.handle.net/123456789/3253-
dc.description25-31en_US
dc.description.abstractThe antioxidant activity of C-Phycocyanin (C-PC) isolated from three cyanobacterial species Lyngbya (marine), Phormidium (marine) and Spirulina (fresh water) was studied in vitro. The results demonstrate that C-PCs from Lyngbya, Phormidium and Spirulina spp. are able to scavenge peroxyl radicals (determined by crocin bleaching assay) with relative rate constant ratio of 3.13, 1.89 and 1.8, respectively. C-PCs also scavenge hydroxyl radicals (determined by deoxyribose degradation assay) with second order rate constant values of 7.87  10¹⁰, 9.58  10¹⁰ and 6.42  10¹⁰, respectively. Interestingly, Lyngbya C-PC is found to be an effective inhibitor of peroxyl radicals (IC₅₀ 6.63 μM), as compared to Spirulina (IC₅₀ 12.15 μM) and Phormidium C-PC (IC₅₀ 12.74 μM) and is close to uric acid (IC₅₀ 2.15 μM). Further, the studies suggest that the covalently-linked tetrapyrrole chromophore phycocyanobilin is involved in the radical scavenging activity of C-PC. The electron spin resonance (ESR) spectra of C-PCs indicate the presence of free radical active sites, which may play an important role in its radical scavenging property. This is the first report on the ESR activity of native C-PCs without perturbations that can cause radical formation.en_US
dc.language.isoen_USen_US
dc.publisherCSIRen_US
dc.relation.ispartofseriesA61K35/74en_US
dc.sourceIJBB Vol.43(1) [February 2006]en_US
dc.subjectC-Phycocyaninen_US
dc.subjectCyanobacteriaen_US
dc.subjectAntioxidanten_US
dc.subjectHydroxyl and peroxyl radical scavengeren_US
dc.subjectElectron spin resonanceen_US
dc.titleAntioxidant potential of C-phycocyanin isolated from cyanobacterial species Lyngbya, Phormidium and Spirulina spp.en_US
dc.typeArticleen_US
Appears in Collections:IJBB Vol.43(1) [February 2006]

Files in This Item:
File Description SizeFormat 
IJBB 43(1) 25-31.pdf820.19 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.