|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.43 [2006] >
IJBB Vol.43(1) [February 2006] >
| Title: | Kinetics and mechanisms of cholesterol esterase inhibition by cardiovascular drugs in vitro |
| Authors: | Chiou, Shyh-Ying
Lai, Gin-Win
Lin, Long-Yau
Lin, Gialih |
| Keywords: | Cholesterol esterase inhibition
Enzyme kinetics
Cardiovascular drugs |
| Issue Date: | Feb-2006 |
| Publisher: | CSIR |
| IPC Code: | C12N9/99 |
| Abstract: | Cardiovascular drugs such as lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride inhibit cholesterol esterase (CEase) in vitro. In the present paper, an attempt was made to determine kinetically the reaction mechanism for CEase inhibition by these drugs. The inhibition constant, Ki, for the mixed-type inhibition of CEase by these drugs in the presence of triton-X-100 or taurochloate were measured. Moreover, the pKi values were correlated with the molecular weights of these drugs. In conclusion, the fact that these drugs lower cholesterol levels in the plasma low-density lipoprotein may be partially due to the CEase inhibition by these drugs. |
| Page(s): | 52-55 |
| ISSN: | 0301-1208 |
| Source: | IJBB Vol.43(1) [February 2006]
|
|
