NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.43 [2006] >
IJBB Vol.43(1) [February 2006] >


Title: Kinetics and mechanisms of cholesterol esterase inhibition by cardiovascular drugs in vitro
Authors: Chiou, Shyh-Ying
Lai, Gin-Win
Lin, Long-Yau
Lin, Gialih
Keywords: Cholesterol esterase inhibition
Enzyme kinetics
Cardiovascular drugs
Issue Date: Feb-2006
Publisher: CSIR
IPC CodeC12N9/99
Abstract: Cardiovascular drugs such as lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride inhibit cholesterol esterase (CEase) in vitro. In the present paper, an attempt was made to determine kinetically the reaction mechanism for CEase inhibition by these drugs. The inhibition constant, Ki, for the mixed-type inhibition of CEase by these drugs in the presence of triton-X-100 or taurochloate were measured. Moreover, the pKi values were correlated with the molecular weights of these drugs. In conclusion, the fact that these drugs lower cholesterol levels in the plasma low-density lipoprotein may be partially due to the CEase inhibition by these drugs.
Page(s): 52-55
ISSN: 0301-1208
Source:IJBB Vol.43(1) [February 2006]

Files in This Item:

File Description SizeFormat
IJBB 43(1) 52-55.pdf83.73 kBAdobe PDFView/Open
 Current Page Visits: 653 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 622495 since 06-Feb-2009  Last updated on 13-Nov-2014Webmaster: nopr@niscair.res.in