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Title: Reactions of some pyrazole-3-carboxylic acids with various N,N'-binucleophiles and investigation of their antiproliferative activities
Authors: Kasımoğulları, Rahmi
Maden, Makbule
Yağlıoğlu, Ayşe Şahin
Mert, Samet
Demirtaş, İbrahim
Keywords: Pyrazole carboxylic acid;N,N'-binucleophiles;Bis-carboxamide;Antiproliferative;Cancer cells
Issue Date: Sep-2015
Publisher: NISCAIR-CSIR, India
Abstract: Synthesis, characterization, and antiproliferative activity evaluation of a series of novel pyrazole bis-carboxamide derivatives (812) have been described. Synthesized molecules have been screened to evaluate their antiproliferative activities against HeLa (human uterus carcinoma), Vero (green monkey kidney), and C6 (Rat Brain tumor) cells as in vitro. The tests are carried out as dose-dependent assay starting from 100 μg/mL to 500 μg/mL. Generally the compounds have been shown to possess weak antiproliferative activity against all cell lines as compared with Cisplatin and 5-Fluorouracil. Only compound 8 shows moderate antiproliferative activity against Hela cancer cells.
Page(s): 1134-1139
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections: IJC-B Vol.54B(09) [September 2015]

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