Please use this identifier to cite or link to this item:
|Title:||Synthesis, characterization and antibacterial activity of some new 3-(3-(trifluoromethyl)-phenyl)-3-(2-hydroxy-5-methylphenyl)-propanehydrazones|
|Authors:||Yatcherla, Srinivasa Rao|
Bollikolla, Hari Babu
|Keywords:||(E)-3-(3-(Trifluoromethyl)phenyl)acrylic acid;p-cresol;Antibacterial activity|
|Abstract:||The present paper describes the synthesis of some new potent antibacterial hydrazide-hydrazone derivatives 6a-j. The synthetic methodology involves preparation of substituted chromen-2-one 3 from the starting materials (E)-3-(3-(trifluoromethyl)phenyl)-acrylic acid 1 with p-cresol 2, which in turn on treatment with hydrazine-hydrate in methanol results in the substituted propane hydrazide 4. Finally, the hydrazones 6a-j have been obtained in 80-88% yield on further condensation with various aromatic aldehydes 5a-j. Compounds 6d, 6e, 6f and 6j exhibit excellent antibacterial activity (zone of inhibition: 26-32 mm) against both the Gram positive (E. coli, P. aeruginosa) and Gram negative bacteria (S. aureus, S. pyogenes) and the compounds 6a, 6b, 6c show good activity (zone of inhibition: 19-27 mm), while the remaining compounds viz., 6g, 6h, 6i show weak activity (zone of inhibition: 10-15 mm).|
|Appears in Collections:|| IJC-B Vol.54B(09) [September 2015]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.