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Title: Synthesis, characterization and antibacterial activity of some new 3-(3-(trifluoromethyl)-phenyl)-3-(2-hydroxy-5-methylphenyl)-propanehydrazones
Authors: Yatcherla, Srinivasa Rao
Islam, Aminul
Dussa, Nageswar
Bollikolla, Hari Babu
Keywords: (E)-3-(3-(Trifluoromethyl)phenyl)acrylic acid;p-cresol;Antibacterial activity
Issue Date: Sep-2015
Publisher: NISCAIR-CSIR, India
Abstract: The present paper describes the synthesis of some new potent antibacterial hydrazide-hydrazone derivatives 6a-j. The synthetic methodology involves preparation of substituted chromen-2-one 3 from the starting materials (E)-3-(3-(trifluoromethyl)phenyl)-acrylic acid 1 with p-cresol 2, which in turn on treatment with hydrazine-hydrate in methanol results in the substituted propane hydrazide 4. Finally, the hydrazones 6a-j have been obtained in 80-88% yield on further condensation with various aromatic aldehydes 5a-j. Compounds 6d, 6e, 6f and 6j exhibit excellent antibacterial activity (zone of inhibition: 26-32 mm) against both the Gram positive (E. coli, P. aeruginosa) and Gram negative bacteria (S. aureus, S. pyogenes) and the compounds 6a, 6b, 6c show good activity (zone of inhibition: 19-27 mm), while the remaining compounds viz., 6g, 6h, 6i show weak activity (zone of inhibition: 10-15 mm).
Page(s): 1162-1167
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections: IJC-B Vol.54B(09) [September 2015]

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