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Title: Synthesis of (S,Z)-5-amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one
Authors: Hongmin, Li
Bin, Wang
Shuyong, Mu
Keywords: (S,Z)-5-Amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one;Simplification;Ritonavir;Lopinavir;Cyanidation
Issue Date: Sep-2015
Publisher: NISCAIR-CSIR, India
Abstract: -Phenylalanine taken as a starting┬ámaterial is protected with benzyl chloride and procedure simplified by not charging with ethyl alcohol. Subsequently with the further simplification of skipping the atmospheric distillation of MTBE (methyl tert-butyl ether), (S,Z)-5-amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one, the significant intermediate of Ritonavir and Lopinavir, is obtained from cyanidation, Grignard reaction and reduction.
Page(s): 1154-1156
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections: IJC-B Vol.54B(09) [September 2015]

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