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Title: Synthesis of some 1,2,4-triazoles as potential anti-tubercular agents
Authors: Vijayaraghavan, S
Shirodkar, P Y
Keywords: 1,2,4-triazole;Anti-tubercular activity
Issue Date: Sep-2015
Publisher: NISCAIR-CSIR, India
Abstract: A series of 5-(N-substituted carboxamidoethylthio)-3-(3′pyridyl)-4-amino-1,2,4-triazole derivatives 6a-j have been synthesized and evaluated for anti-tubercular activity. They are screened in-vitro at 10µg/mL concentration against Mycobacterium tuberculosis H37RV (ATCC 27294). All the compounds are showing anti-tubercular activity when compared with the standard drug Amikacin. Compounds 6e and 6h are found active as they displayed IC50 and IC90 values at < 100μg/mL.
Page(s): 1149-1153
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections: IJC-B Vol.54B(09) [September 2015]

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