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Title: Oxidation of amoxicillin by hexacyanoferrate(III) in aqueous alkaline medium—A kinetic and mechanistic approach
Authors: Durgannavar, Amar K
Patgar, Manjanath B
Chimatadar, Shivamurti A
Keywords: Kinetics;Reaction mechanism;Oxidation;Amoxicillin;Hexacyanoferrate(III)
Issue Date: Sep-2015
Publisher: NISCAIR-CSIR, India
Abstract: The kinetics and mechanism of oxidation of amoxicillin by hexacyanoferrate(III) in aqueous alkaline medium at constant ionic strength of 0.10 mol dm-3 is studied spectrophotometrically at 25 °C. The reaction exhibits 2:1 ([Fe(CN)6]3-: amoxicillin) stoichiometry. The reaction products have been identified with the help of TLC and characterized by FT-IR, GCMS and LCMS. The reaction is first order in hexacyanoferrate(III) concentration but fractional order in both amoxicillin and alkali concentrations. The effects of ionic strength and dielectric constant have been investigated. In a composite equilibrium step, amoxicillin binds to hexacyanoferrate(III) to form a complex that subsequently decomposes to the products. Based on investigation of the reaction at different temperatures, computation of the activation parameters with respect to the slow step of the proposed mechanism was evaluated.
Page(s): 1085-1091
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.54A(09) [September 2015]

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