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Title: The effect of administration of Pasak bumi (Eurycoma longifolia Jack.) roots to haematological profile of lactating mice
Authors: Panjaitan, Ruqiah Ganda Putri
Keywords: Eurycoma longifolia Jack.;Lactating mice;Haematological profile
Issue Date: Apr-2015
Publisher: NISCAIR-CSIR, India
IPC Code: Int. Cl.8: A61K 36/00, G01N 33/04, C13K 5/00, A61B 5/15, C09B 61/00
Abstract: The roots of Pasak bumi have been used as a traditional medicine as tonic after childbirth in Indonesia. However, the usefulness of its is still empiric. The aim of this research is to evaluate the effect of pasak bumi roots methanol extract and its derived fraction to haematological profile of lactating mice. Each mouse was administered methanol extract and its derived fractions (n-hexane fraction, chloroform fraction, ethyl acetate fraction, and methanol-water fraction) at dose 500 mg/kg rat body weight for 21 consecutive days in lactation period. Positive control group received Moloco+B12 at dose 0.13 gm/kg rat body weight, negative control (placebo) group received 2 mL/kg rat body weight of aquadest daily, and normal control group. There were no significant differences in erythrocytes count, haemoglobin, and haematocrit value among the groups during the study (p>0.05). On the contrary, leukocytes count of methanol extract was higher than normal control, placebo, positive control, and derived fractions of methanol extract (p<0.05), but the differentiation of leukocytes (neutrophils, eosinophils, basophils, lymphocytes, and monocytes) were not significantly different (p>0.05). It can be concluded that the methanol extract haematological profile is more similar to physiological value.
Page(s): 231-235
ISSN: 0975-1068 (Online); 0972-5938 (Print)
Appears in Collections:IJTK Vol.14(2) [April 2015]

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