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Title: Synthesis and biological screening of novel pyrazole and isoxazole derivatives
Authors: Raundal, Hemant N
Jadhav, Rahul P
Patil, Amar A
Bobade, Vivek D
Keywords: Pyrazole;Isoxazole;Antibacterial;Antifungal
Issue Date: Aug-2015
Publisher: NISCAIR-CSIR, India
Abstract: Novel 1,5-disubstituted pyrazole and isoxazole derivatives like, aryl 5-(3-fluoro-4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid 8a-e, [(aryl)-piperazin-1-yl]-[5-(3-fluoro-4-methoxyphenyl)-isoxazol-3-yl]-methanone 9a-e, aryl 5-(3-fluoro- 4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid 10a-e have been synthesized and characterized using IR, 1H NMR, 13C NMR and mass spectral analysis. All the synthesized compounds have been screened for their antibacterial activity against S. aureus, E. coli, B. subtilis, P. aeruginosa, S. pyogenes, K. terrigena and K. pneumoniae and antifungal activity against T. viride, A. flavus, A. brasillansis, and C. albicans. Interestingly all the synthesized compounds exhibit good antibacterial and antifungal activity.
Page(s): 979-987
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections: IJC-B Vol.54B(08) [August 2015]

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