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|Title:||Effect of Aegle marmelos seed extract on hypoglycemic activity of experimental rats|
|Authors:||Kesari, Achyut Narayan|
Gupta, Rajesh Kumar
|Abstract:||Aegle marmelos Corr. (Rutaceae) is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. The aqueous extract of Aegle marmelos seeds was administered orally at different doses (100, 250 & 500 mg/kg) to normal as well as sub (FBG normal; glucose tolerance abnormal) and mild (FBG 120-250 mg/dl) diabetic rats. Initial testing was carried with the different doses of the seed extract in normal healthy rats fasted overnight. The animals were divided into groups. Control rats (group I) were given distilled water only while other groups II, III and IV received aqueous seed extract suspended in distilled water orally at doses 100, 250 and 500 mg/kg, respectively. The dose of 250 mg/kg was found to be most effective dose and it decreases blood glucose level (BGL) by 35.1 % in normal healthy rats after 6 h of administration. The hypoglycemic effect of aqueous extract of A. marmelos seeds in sub and mild diabetic rats was assessed by improvement of glucose tolerance. FBG was checked in overnight fasted rats and were divided in to several groups. Control groups of sub and mild diabetic animals received distilled water only, whereas variable doses of 100, 250 and 500 mg/kg of aqueous seed extract were administered orally to rest of the groups of each, sub and mild diabetic animals. The rats of all the groups were given glucose (3 g/kg) after 90 min of the extract and drug administration. Blood samples were collected just prior to glucose administration (0 h) and I, 2 and 3 h after glucose loading. The dose of 250 mg/kg again showed a marked reduction in BGL of 41.2% in sub and 33.2% in mild diabetic rats in glucose tolerance test after 2 h. The findings from this study suggest that the aqueous extract of these seeds may be prescribed as adjunct to dietary therapy and drug treatment for controlling diabetes mellitus.|
|Appears in Collections:||BVAAP Vol.15(1) [June 2007]|
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