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Title: Role of tetracycline and cAMP analogues in pancreatic β stem cell differentiation/proliferation process via modulation of epac2 protein
Authors: Tripathi, Anushree
Misra, Krishna
Keywords: cAMP;Epac2;Glucagon like peptide1;Stem cell;Tetracycline
Issue Date: Apr-2015
Publisher: NISCAIR-CSIR, India
Abstract: For effective treatment of diabetes, appropriate pancreatic β stem cell proliferation enhancers and differentiation deactivators have to be designed and developed. The aim of the present work was to understand the nature and affinity of epac2 protein against analogues of tetracycline as deactivators and cAMP as activator for the pancreatic β cells. The peculiarity of this epac2 protein lies in the activation of proliferating activity of pancreatic β cells via stimulating glucagon like peptide1 (GLP1). This in turns induces Ca2+ signalling and insulin secretion. In the present work, docking simulation and pharmacophore study was carried out on cAMP and tetracycline analogues to predict the potential activator as well as deactivator of the proliferation and differentiation of pancreatic β stem cells. It was observed that some analogues of cAMP better contribute to the proliferative activities in comparison with cAMP itself. Moreover, some tetracycline analogues are likely to be more effective for the deactivation of proliferation and differentiation process of pancreatic β stem cells. The present study is likely to lead to the discovery of significant potential therapy for diabetes.
Page(s): 172-178
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.14(2) [April 2015]

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