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|Title:||Assessment of free-radical scavenging activities of mangiferin from Curcuma amada obtained by non-conventional extraction methods: A comparative study|
|Keywords:||IC50 value;Mangiferin;Microwave assisted extraction;Nutraceuticals aspect;Radical scavenging|
|Abstract:||Mangiferin (MgFn) is a naturally occurring bioactive glucosylxanthone having numerous pharmacological activities. A feasible microwave assisted extraction (MAE) technique for extraction of MgFn from Curcuma amada (mango ginger) was developed in our laboratory. To prove the efficacy of MAE technique, it was compared with other methods like maceration extraction (ME) and ultrasonic sound assisted extraction (UAE). A high yield of MgFn was obtained by MAE (1.472 mg/g) compared to 1.017 mg/g yield by UAE and 0.837 mg/g by ME technique in acetone-water (50:50 v/v). Scanning electron microscopy (SEM) photographs of C. amada cells were taken, which were subjected to different extraction forces mentioned above. The efficacy of MgFn as a radical scavenger was studied using 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), nitrate scavenging and ferric reducing power assays. The IC50 value of MgFn extracted with MAE was recorded to be 26 µg/mL; showing it to be an effective radical scavenger more efficient than ascorbic acid.|
|ISSN:||0975-0967 (Online); 0972-5849 (Print)|
|Appears in Collections:||IJBT Vol.14(2) [April 2015]|
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