Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/31785
Title: An efficient and straight forward strategy for the synthesis of enantiomerically pure (S)-1-benzyl-5-(alkyl/aryl amino) methyl)-pyrrolidin-2-ones
Authors: Panday, Sharad Kumar
Pathak, Manoher Bhushan
Prasad, Jagdish
Keywords: Enantiomerically pure;Dysibetaine;4,5-diaminovaleric acid (DAVA);Conformationally restricted PNA analogues;(S)-5-((Alkyl/aryl amino) methyl) pyrrolidin-2-ones
Issue Date: Jul-2015
Publisher: NISCAIR-CSIR, India
Abstract: A simple, efficient and straightforward strategy for the synthesis of enantiomerically pure (S)-5-((alkyl/aryl amino) methyl)-pyrrolidin-2-ones from N-benzyl-5(S)-pyroglutaminol through Mitsunobu reaction has been described. These pyrrolidin-2-ones have great potential to act as asymmetric precursors for the synthesis of bioactive compounds/ natural products requiring suitably substituted aminomethyl group at C-5 of native pyrrolidin-2-ones.
Page(s): 936-939
URI: http://hdl.handle.net/123456789/31785
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.54B(07) [July 2015]

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