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|Title:||An efficient and straight forward strategy for the synthesis of enantiomerically pure (S)-1-benzyl-5-(alkyl/aryl amino) methyl)-pyrrolidin-2-ones|
|Authors:||Panday, Sharad Kumar|
Pathak, Manoher Bhushan
|Keywords:||Enantiomerically pure;Dysibetaine;4,5-diaminovaleric acid (DAVA);Conformationally restricted PNA analogues;(S)-5-((Alkyl/aryl amino) methyl) pyrrolidin-2-ones|
|Abstract:||A simple, efficient and straightforward strategy for the synthesis of enantiomerically pure (S)-5-((alkyl/aryl amino) methyl)-pyrrolidin-2-ones from N-benzyl-5(S)-pyroglutaminol through Mitsunobu reaction has been described. These pyrrolidin-2-ones have great potential to act as asymmetric precursors for the synthesis of bioactive compounds/ natural products requiring suitably substituted aminomethyl group at C-5 of native pyrrolidin-2-ones.|
|Appears in Collections:||IJC-B Vol.54B(07) [July 2015]|
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