Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/31782
Title: Synthesis and antifungal activity of 1, 5-diaryl pyrazole substituted thiazole derivatives
Authors: Patil, Amar
Jadhav, Rahul
Raundal, Hemant
Patil, Sachin
Bobade, Vivek
Sharma, Lokesh
Badgujar, Rupali
Keywords: Pyrazole-thiazole;Antifungal activity;MIC;MFC;Biological assay
Issue Date: Jul-2015
Publisher: NISCAIR-CSIR, India
Abstract: Series of eight derivatives of 5-bistrifluoromethyl phenyl pyrazole substituted thiazole have been prepared and characterized by 1H and 13C NMR, and mass spectrometry. All the synthesized derivatives have been screened for antifungal activity against four fungal pathogens such as Candida albicans, Aspergillus flavus, Aspergillus fumigatus and Aspergillus niger using broth microdilution method. Active compounds have also been screened for MIC (minimum inhibitory concentration) and MFC (minimum fungicidal concentration). Three compounds 8b, 8f and 8h are found to be equi-potent with standard drug actidione, against Candida albicans and Aspergillus flavus strains.
Page(s): 918-923
URI: http://hdl.handle.net/123456789/31782
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.54B(07) [July 2015]

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