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|Title:||Synthesis, characterization and antibacterial evaluation of some novel hydrazone derivatives of 3-chloro-4-hydroxy-benzoic acid|
|Authors:||Chandrasekhar, K B|
|Keywords:||Antibacterial activity;Benzaldehyde;3-chloro-4-hydroxybenzoic acid;Hydrazide-hydrazone|
|Abstract:||Hydrazide-hydrazones have gained great importance due to their diverse biological properties, including anti-inflammatory, antimalarial and antituberculotic activities. With the aim of obtaining novel hydrazide-hydrazones with a wide spectrum of pharmaceutical applications, herein is reported the synthesis and antibacterial activity of a series of fifteen new hydrazide-hydrazones derivatives synthesized from coupling of methyl-3-chloro-4-hydroxybenzoate and 3-chloro-benzylchloride 3. The newly synthesized fifteen hydrazone derivatives 6a-o have been screened against four chosen bacterial strains viz., E. coli, P. aeruginosa, S. aureus and S. pyogenes with ampicillin as the standard drug. It is observed that compounds 6m (2,4-di-fluoro), 6n (3,4-di-fluoro) and 6o (2-methyl-4-fluro) exhibit excellent antibacterial activity (zone of inhibition 21-24 mm), while compounds 6j, 6k, 6l having 4-CF3, 4-OCF3 and 2-CF3 substituents display equipotent antibacterial activity (zone of inhibition 19-22 mm).|
|Appears in Collections:||IJC-B Vol.54B(07) [July 2015]|
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