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Title: Evaluation of radioprotective effects of Opuntia elatior extract on catalase and superoxide dismutase activity in mouse liver
Authors: Mathur, Aarti
Sharma, Jaimala
Issue Date: Jun-2015
Publisher: NISCAIR-CSIR, India
Abstract: Ionizing radiations affect the living systems by damaging the vital macromolecules and structures of the target cell. A number of chemical and synthetic compounds have radioprotective potential but their high toxicity limits clinical application. Therefore, development of less toxic and potential drug of plant origin for the modification of radiation effects is required. Adult male Swiss albino mice were selected and divided into four groups. Group I was sham irradiated. Group II was fed with OE only (10 mg/kg body weight). Group III was irradiated with 8Gy Co60 gamma irradiation and Group IV was given OE one hour before irradiation. Mice were sacrificed at various post irradiation intervals to analyse the Catalase and Superoxide dismutase (SOD) activity in the liver. Results were subjected to students 't' test. The activity of both SOD and Catalase were found to be decreased till 7th day post irradiation in control group while a significant increase was observed in the OE pretreated irradiated group as compared to the control groups at all the intervals. Opuntia elatior extract pretreatment provides protection against radiation induced changes in the Catalase and SOD activity in the mouse liver.
Page(s): 31-35
ISSN: 0975-2412 (Online); 0771-7706 (Print)
Appears in Collections:BVAAP Vol.23(1) [June 2015]

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