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Title: Functional modification of agarose: Synthesis of nanosize half-esters of succinic, phthalic and maleic acids
Authors: Kondaveeti, S
Chudasama, N A
Chaudhary, J P
Meena, R
Siddhanta, A K
Keywords: Agarose;Polysaccharides;Functional modification;Succinoylation;Phthaloylation;Maleoylation
Issue Date: 11-Jun-2015
Publisher: NISCAIR-CSIR, India
Abstract: A facile synthetic method for preparing new half-esters of agarose (Ag) with succinic (SA), phthalic (PA) and maleic (MA) acids has been described. The half-esters (Ag-SA, Ag-PA and Ag-MA) wherein the acid moieties are attached to the backbone of the agarose are characterized. Dynamic light scattering measurements show that nano-sized polymeric vesicles (32-124 nm) are formed in aqueous solution. A series of Ag-SA, Ag-PA and Ag-MA derivatives have been prepared with degrees of substitution ranging from 0.36 to 0.89 using varying molar ratios of Ag/SA, Ag/PA and Ag/MA (1:1–1:5). The highest degrees of substitution are found to be 0.89, 0.69 and 0.39 for Ag-SA (1:4), Ag-PA (1:3) and Ag-MA (1:2) respectively. The aqueous solution of sodium salts of these esters exhibit enhanced electrical conductivity (ca. 17.5 mS/cm at 40 °C) as compared to those of the parent half-esters (ca. 0.3 mS/cm at 40 °C). These new agarose based nanosized materials may have potential applications in electrochemical devices, sensors and as drug carriers.
Page(s): 734-743
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections: IJC-A Vol.54A(06) [June 2015]

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