Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/31663
Title: Synthesis of chalcone derivatives of benzo[b]furan as potential antibacterial agents
Authors: V, Krishna Reddy
J, Venkateswara Rao
L, Bhaskar Reddy
B, Ram
B, Balram
Keywords: Synthesis;Benzo[b]furan;Norfloxacin;Antibacterial activity
Issue Date: Jun-2015
Publisher: NISCAIR-CSIR, India
Abstract: Encouraged by the interesting biological activities associated with chalcones and benzo[b]furan derivatives, herein are reported the synthesis, spectroscopic identification and antibacterial activity of benzo[b]furan chalcone derivatives 6a-o derived from 1-(7-methoxy-2-(2,4,6-trimethoxyphenyl)benzofuran-5-yl)ethanone 5 in a few high yielding steps from commercially available 1,3,5-trimethoxybenzene and 5-iodovanillin and various benzaldehydes. The synthesized targets have been screened for their antibacterial activity against Escheria coli, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococus pyogenes, while using Norfloxacin as the standard drug. Among all the compounds 6a-o, the compounds 6n, 6o, 6l and 6m exhibit excellent to equipotent activity while the compounds having the alkoxy substituent in the series display good to moderate activity.
Page(s): 791-797
URI: http://hdl.handle.net/123456789/31663
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.54B(06) [June 2015]

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